Development of Natural Products for Lowering Blood Lipids

[Study on natural products for drug development].

The ubiquitin-proteasome system (UPS) plays a major role in selective protein degradation and regulates various cellular events. Approval of bortezomib for the treatment of multiple myeloma validated the proteasome as an anticancer target. In order to find drug candidates targeting the ubiquitin-dependent protein degradation, we paid an attention to inhibitors against three enzymes, ubiquitin-a...

A New Perspective on the Development of Cholesterol-Lowering Products

Discovery, Development, and Regulation of Natural Products

Natural products have historically been an extremely productive source for new medicines in all cultures and continue to deliver a great variety of structural templates for drug discovery and development. Although products derived from natural sources may not necessarily represent active ingredients in their final form, the majority of all drugs in the market have their origin in nature [1, 2]....

Targets for Body Fat, Blood Pressure, Lipids, and Glucose-Lowering Interventions in Healthy Older People

Improving cardiovascular (CV) risk profile, by lowering elevated body weight, blood pressure (BP), plasma cholesterol, and blood glucose (BG) levels, is of relevance for decreasing fatal and nonfatal CV events in young and middleaged patients (1–4). Evidence also exists that the above-mentioned interventions are also highly effective in older patients, i.e., in subjects .65 years of age (3–6). ...

development and implementation of an optimized control strategy for induction machine in an electric vehicle

in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...